San Diego BiosciencesOverview
BPs San Diego Biosciences Center (BSC) conducts research, supports investments and manages academic partnerships aimed at accelerating the worlds transition to a lower carbon future.
We are scientist founded, scientist driven. In addition to our innovative portfolio of over 4000 products, our core of Ph.D. scientists are experts in the design, expression, purification, and characterization of active recombinant enzymes and enzyme complexes. We are also highly skilled in developing recombinant cell lines and all aspects of biochemical and cell-based assay development. As a primary manufacturer, BPS can supply products in large-scale bulk quantities and welcomes inquiries for contract and custom manufacturing within a variety of research areas.
BPS has developed stable, recombinant cell lines expressing cancer antigens at different expression levels–high, medium, or low expression. These cell lines are ideal to monitor the effectiveness of different CAR-T at detecting the target antigen expressed at different levels, which may relate to the time dependence of antigen expression. The FACS data analysis to the right shows several BCMA-expressing cell lines detected by a PE-labeled antibody, vs. the control cell line.
BPS also offers biotin-labeled versions of many of the antigens recognized by CAR-T cells, such as BCMA, CD19, CD22, CD123, CD38, and ROR1. These biotin-labeled proteins can bind to CAR-T cells and be detected by flow cytometry using PE-streptavidin, in order to verify that the CAR-T cell is recognizing and binding the specific cancer antigen.
Engineering T cells to boost the immune system has potential benefits beyond cancer treatment, including treatments for chronic inflammatory diseases such as hepatitis, HIV/AIDS, lupus, and arthritis. Companies are also investigating CAR T-cell therapy in organ transplantation to eliminate the need for lifelong immunosuppressants. The future is bright for CAR-T research, and BPS Bioscience continues to develop unique cell lines and other tools to help researchers create, evaluate, and enhance CAR-T cells for the improvement of human health.
4955 Directors Way, San Diego, California 92121 US
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